Page 912 - Adams and Stashak's Lameness in Horses, 7th Edition

878 Chapter 8

progression of OA; their effect was also measured at a chronic back soreness secondary to pain associated with
dose lower than what’s required to inhibit bacterial the axial skeleton or as a component of multimodal
VetBooks.ir that orally administered doxycycline was able to pene- and opiate treatment. Dosages range from 5 to 20 mg/kg
analgesia for musculoskeletal pain refractory to NSAID
growth. Follow‐up work from the same group reported
19
PO two to three times daily with dosages being titrated
trate and accumulate within the synovial fluid, and
62
when administered to horses orally at 5 mg/kg every 24 to effect. 37
hours for four doses, synovial fluid obtained from Manufacturer’s Details
treated horses had significantly reduced MMP‐13 a Osphos , Dechra Veterinary Products, Overland
®
expression. At that time, the authors supported the use Park, KS.
47
of doxycycline as a disease‐modifying drug for OA. 47
References
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17
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