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Infectious Laryngotracheitis Virus | 321

Table 11.1. Open reading frames and proteins encoded within the ILTV genome
Open Predicted Apparent
reading Predicted molecular molecular
frame amino acid mass mass
(ORF) Protein length a (kDa) b (kDa) Putative function Transcribed References
UL56 Membrane protein UL56 275 30.5 ND Uncharacterised
ORF F Protein IF 747 81.9 ND Uncharacterised
UL54 Posttranslational 545 62.2 ND Gene regulation, RNA α Johnson et al. (1995a);
regulator of gene metabolism and transport E II Mahmoudian et al. (2012)
expression ICP27
UL53 Glycoprotein K 340 38.9 ND Virion morphogenesis – γ Johnson et al. (1995a);
Membrane fusion E/L II Mahmoudian et al. (2012)
UL52 Helicase-primase 1111 123.7 ND DNA replication γ Johnson et al. (1995a);
primase subunit L I Mahmoudian et al. (2012)
UL51 Tegument protein 230 25.2 ND Virion morphogenesis. E/L I Mahmoudian et al. (2012)
Detected but not
characterized
UL50 c Deoxyuridine 413 44.7 ND Nucleotide metabolism. E/L I Fuchs et al. (2000);
triphosphatase DUL50 used as vector for Mahmoudian et al. (2012)
HPAI vaccines
UL49.5 c Glycoprotein N d 118 12.7 17 Virion morphogenesis L III Ziemann et al. (1998a);
– Membrane fusion. Fuchs and Mettenleiter
Interacts with UL10 (2005); Mahmoudian et
and immunoprecipitate al. (2012)
together
UL49 Tegument protein VP22 267 30.4 34 Virion morphogenesis – γ (β) Ziemann et al. (1998a);
Possibly RNA transport E III Helferich et al. (2007a);
to uninfected cells Mahmoudian et al. (2012)
UL48 Viral tegument protein 397 44.6 45 Virion morphogenesis – γ (β) Ziemann et al. (1998a);
α-TIF VP16 Gene regulation E III Helferich et al. (2007a);
Mahmoudian et al. (2012)
UL46 Tegument 558 62.7 64 Gene regulation γ (α, β) Ziemann et al. (1998a);
phosphoprotein VP11/12 E/L I Helferich et al. (2007a);
Mahmoudian et al. (2012)
UL45 Tegument/envelope 282 30.6 ND Membrane fusion L III Ziemann et al. (1998a);
protein Mahmoudian et al. (2012)
ORF A c ILTV Unique Protein IA d 377 41.3 40 Unknown α > β < γ1 Ziemann et al. (1998a);
< γ2 Veits et al. (2003c);
L II Mahmoudian et al. (2012)
ORF B c ILTV Unique Protein IB d 341 38.1 34 Unknown β = γ1 < γ2 Ziemann et al. (1998a);
L II Veits et al. (2003c);
Mahmoudian et al. (2012)
ORF C c ILTV Unique Protein IC d 336 37.4 38, 30 Cell-to-cell spread α = β < γ1 Ziemann et al. (1998a);
> γ2 L II Veits et al. (2003c);
Mahmoudian et al. (2012)
ORF D c ILTV Unique Protein ID d 375 41.5 41 Unknown β < γ1 > γ2 Ziemann et al. (1998a);
EL II Veits et al. (2003c);
Mahmoudian et al. (2012)
ORF E c ILTV Unique Protein IE d 411 45.1 44 Unknown α = β < γ1 Ziemann et al. (1998a);
> γ2 Veits et al. (2003c);
L II Mahmoudian et al. (2012)
UL22 Glycoprotein H 805 89.4 92 Cell entry (fusogen in L I Ziemann et al. (1998a);
complex with gL) – Mahmoudian et al. (2012)
Cell-to-cell spread
UL23 c Thymidine kinase 364 40.3 ND Nucleotide metabolism E I Schnitzlein et al. (1995);
Ziemann et al. (1998a);
Han et al. (2002);
Mahmoudian et al. (2012)
UL24 Nuclear protein UL24 288 32.2 ND Unknown L II Mahmoudian et al. (2012)
UL25 DNA packaging 593 66.4 ND DNA encapsidation E II Mahmoudian et al. (2012)
tegument protein UL25
UL26 Capsid maturation 587 65.4 ND Capsid morphogenesis L II Mahmoudian et al. (2012)
protease