Page 1354 - Saunders Comprehensive Review For NCLEX-RN

2. Cell cycle phase–specific; act on the G and S phases
2
B. Side and adverse effects
1. Leukopenia, thrombocytopenia, and anemia
2. Anorexia, nausea, and vomiting
3. Diarrhea
4. Alopecia
5. Orthostatic hypotension
6. Hypersensitivity reaction

C. Interventions: Refer to Section I, C (Antineoplastic

Medications—General Interventions).
VII. Hormonal Medications and Enzymes (Box 45-6)
A. Description
1. Suppress the immune system and block normal
hormones in hormone-sensitive tumors
2. Change the hormonal balance and slow the growth
rates of certain tumors
B. Side and adverse effects
1. Anorexia, nausea, and vomiting
2. Leukopenia
3. Impaired pancreatic function with asparaginase
4. Sex characteristic alterations
a. Masculinizing effect in women: Chest
and facial hair, menses stops
b. Feminine manifestations in men:
Gynecomastia
5. Breast swelling
6. Hot flashes
7. Weight gain
8. Hemorrhagic cystitis, hypouricemia, and
hypercholesterolemia, with mitotane
9. Hypertension
10. Thromboembolic disorders
11. Edema
12. Electrolyte imbalances

13. Tamoxifen citrate may cause edema,

hypercalcemia, and elevated cholesterol and
triglyceride levels.

14. Tamoxifen citrate decreases the effects of

estrogen.

C. Interventions: Refer to Section I, C (Antineoplastic

Medications—General Interventions).
1. Assess medications that the client is taking currently.

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