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CHAPTER 46



               Endocrine Problems




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               Priority Concepts
               Glucose Regulation; Hormonal Regulation


                    I. Anatomy and Physiology of Endocrine Glands (Box 46-1)
                                A. Functions
                                             1. Maintenance and regulation of vital functions
                                             2. Response to stress and injury
                                             3. Growth and development
                                             4. Energy metabolism
                                             5. Reproduction
                                             6. Fluid, electrolyte, and acid-base balance
                                B. Risk factors for endocrine problems (Box 46-2)
                                C. Hypothalamus (Box 46-3)
                                             1. Portion of the diencephalon of the brain, forming the
                                                floor and part of the lateral wall of the third ventricle
                                             2. Activates, controls, and integrates the peripheral
                                                autonomic nervous system, endocrine processes, and
                                                many somatic functions, such as body temperature,
                                                sleep, and appetite
                                D. Pituitary gland (Box 46-4; Fig. 46-1)
                                             1. The master gland; located at the base of the brain
                                             2. Influenced by the hypothalamus; directly affects the
                                                function of the other endocrine glands
                                             3. Promotes growth of body tissue, influences water
                                                absorption by the kidney, and controls sexual
                                                development and function
                                E. Adrenal gland
                                             1. One adrenal gland is on top of each kidney.
                                             2. Regulates sodium and electrolyte balance; affects
                                                carbohydrate, fat, and protein metabolism; influences
                                                the development of sexual characteristics; and
                                                sustains the fight-or-flight response
                                             3. Adrenal cortex
                                                             a. The cortex is the outer shell of the
                                                                adrenal gland.
                                                             b. The cortex synthesizes glucocorticoids
                                                                and mineralocorticoids and secretes


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