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104  Clinical Pearls in Cardiology


                   guidelines advocate surgical intervention in the form of
                   heart transplantation, rather than mitral annuloplasty,
                   in patients with severe functional MR and depressed
                   left ventricular function, who are symptomatic despite
                   maximal medical therapy for heart failure (Ref: Heart.
                   BMJ. 2011;97:1012–23).
                8.  What are the important differentiating features
                   between acute and chronic mitral regurgitation?
                   The important features that help to distinguish acute
                   mitral regurgitation from chronic mitral regurgitation
                   are the following (Table 1).
                   Table 1: Distinction between acute mitral regurgitation
                   and chronic mitral regurgitation
                                Chronic MR             Acute MR
                   Chronic MR  Chronic MR  Chronic MR
                   (Rheumatic)  (Functional)  (MVP)
                   Usually occurs  Is the result   Due to the   Due to the
                   as the sequale  of annular   floppy mitral   ischemic
                   of past attack   dilatation   valve in mitral   rupture of
                   of rheumatic   secondary to   valve prolapse  chordae
                   fever       the dilatation          or papillary
                               of the left             muscle
                               ventricle
                   Isolated MR is   Valve cusps   May be due to   Due to the
                   rare        are normal  the contractile   perforation
                                          dysfunction of   of the valve
                                          the postero-   cusps in
                                          medial papillary   endocarditis
                                          muscle in
                                          chronic      Due to blunt
                                          myocardial   chest trauma
                                          ischemia

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