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RETIREMENT SAVINGS



          NEWPORT GROUP | 401(K)
          You are encouraged to participate in Puma Biotechnology’s 401(k) plan. You will be eligible to participate in
          the Plan when you have satisfied the completion of 3 months of service. As a Participant under the Plan, you
          may elect to reduce your compensation by a specific percentage or dollar amount and have that amount
          contributed to the Plan as a salary deferral. There are two types of salary deferrals: Pre-Tax 401(k) deferrals
          and Roth 401(k) deferrals. For purposes of this SPD, “salary deferrals” generally means both Pre-Tax 401(k)
          deferrals and Roth 401(k) deferrals. Regardless of the type of deferral you make, the amount you defer is
          counted as compensation for purposes of Social Security taxes.
          Pre-Tax 401(k) deferrals. If you elect to make Pre-Tax 401(k) deferrals, then your taxable income is reduced
          by the deferral contributions so you pay less in federal income taxes. Later, when the Plan distributes the
          deferrals and earnings, you will pay the taxes on those deferrals and the earnings. Therefore, with a Pre-Tax
          401(k) deferral, federal income taxes on the deferral contributions and on the earnings are only postponed.
          Eventually, you will have to pay taxes on these amounts.

          Roth 401(k) deferrals. If you elect to make Roth 401(k) deferrals, the deferrals are subject to federal income
          taxes in the year of deferral. However, the deferrals and, in most cases, the earnings on the deferrals are
          not subject to federal income taxes when distributed to you. In order for the earnings to be tax free, you
          must meet certain conditions.

           401(K) IRS MAXIMUMS                               2018                             2019

           Employee Deferral                                $18,500                    Indexed for Inflation
           Catch-up Deferral for Employees                  $6,000                     Indexed for Inflation
           Over the Age of 50

          Puma Biotechnology will make a discretionary match in the following amounts:
           •   100% of your first 3% contribution              •   50% of your 4-5% contribution

          Puma Biotechnology’s employer match is immediately vested once your contributions begin.


                      FOR MORE INFORMATION OR TO ENROLL:
                      Contact the Human Resources Department.


          COST OF COVERAGE



          The following benefits are provided to you and your eligible dependents at no charge and are paid by Puma
          Biotechnology:
           •   Medical             •   Dental      •   Employee Assistance Program        •   Short Term Disability
           •   Health Advocate     •   Vision      •   Basic Life and AD&D                •   Long Term Disability

          The following benefits are available to you at discounted group rates. Should you elect these benefits, you
          will pay 100% of the cost:
           •   Voluntary Life and AD&D                       •   Pet Insurance

          Puma will continue to revisit our plan offerings at the end of each plan period, or as business needs change, and
          may make future plan changes as necessary. Puma will continue to try to minimize the impact to our employees.

               Puma Biotechnology offers employees who waive medical coverage, and can document credible
                coverage elsewhere, a $250 per month cash-in-lieu credit. This benefit will be paid out in equal
                                installments coinciding with your respective payroll frequency.
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