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A28    SCIENCE
                   Wednesday 12 June 2019
            Marijuana health claims lure patients as science catches up



            By CARLA K. JOHNSON          made  from  CBD,  to  treat   tients with AIDS or cancer.  In one study, nine patients  Such  challenges  are  com-
            AP Medical Writer            two  rare  seizure  disorders.   And  researchers  continue  with  an  aggressive  form  mon  for  scientists  studying
            SEATTLE  (AP)  —  Marijuana  THC  causes  marijuana’s     to study whether marijuana  of  brain  cancer  had  THC  an  outlaw  medicine,  said
            has  been  shown  to  help  mind-altering  effect;  CBD   helps with PTSD, back pain  injected  into  their  tumors;  Dr. Igor Grant, who directs
            ease pain and a few other  doesn’t get people high.       and other problems.          any effect on their survival  the  oldest  marijuana  re-
            health  problems,  yet  two-                                                                                        search center in the U.S. at
            thirds  of  U.S.  states  have                                                                                      the University of California,
            decided  pot  should  be                                                                                            San Diego.
            legal  to  treat  many  other                                                                                       There,  scientists  are  study-
            conditions  with  little  scien-                                                                                    ing  marijuana  chemicals
            tific backing.                                                                                                      for children with autism and
            At  least  1.4  million  Ameri-                                                                                     adults with a brain disorder
            cans  are  using  marijuana                                                                                         that causes uncontrollable
            for  their  health,  accord-                                                                                        shaking.   Established   by
            ing to an Associated Press                                                                                          state law in 2000, the Cen-
            analysis of states that track                                                                                       ter for Medicinal Cannabis
            medical  marijuana  pa-                                                                                             Research once relied solely
            tients.                                                                                                             on  California  for  funding.
            The  number  of  medical                                                                                            The center now has support
            marijuana      cardholders                                                                                          from private foundations, a
            more than tripled in the last                                                                                       sign  of  growing  public  ac-
            five  years  as  more  states                                                                                       ceptance of the research.
            jumped  on  the  bandwag-                                                                                           TRACKING PATIENTS
            on.  The  analysis  is  based                                                                                       Minnesota  medical  mari-
            on data from 26 states and                                                                                          juana  patients  must  regu-
            the  District  of  Columbia.                                                                                        larly  fill  out  surveys  about
            The total climbs to 2.6 mil-                                                                                        their symptoms and side ef-
            lion  patients  if  California,                                                                                     fects. That allows research-
            Washington and Maine are                                                                                            ers  to  study  how  people
            included, the AP estimates.  In this Friday, March 22, 2019 file photo, an employee at a medical marijuana dispensary in Egg   with cancer react to mari-
            States  that  expanded  the   Harbor Township, N.J., sorts buds into prescription bottles.                          juana.
            use of medical pot for com-                                                                        Associated Press  In one study, a third of can-
            mon  ailments  such  as  se-                                                                                        cer patients made only one
            vere  pain,  post-traumatic  British drugmaker GW Phar-   OPIOID ALTERNATIVE?          was unclear. Another study  purchase and didn’t come
            stress  disorder  and  anxiety  maceuticals is seeking U.S.   New  York,  New  Jersey,  found  worrying  evidence  back  during  a  four-month
            saw a boost in enrollment,  approval for Sativex. Other   Pennsylvania   and    New  that  marijuana  might  in-    period.  They  may  have
            the AP found.                companies  are  pursuing     Mexico allow medical mar-    terfere  with  some  cancer  died, or decided marijuana
            The    U.S.   government,  Food and Drug Administra-      ijuana for opioid addiction  drugs, making them less ef-  was too expensive or didn’t
            meanwhile, both considers  tion  backing  for  products   despite  little  evidence  it  fective.                   work.  Of  the  rest,  most  re-
            marijuana  an  illegal  drug  based on marijuana ingre-   works.                       RESEARCHING  AN  OUTLAW  ported  improvements  in
            and  a  therapeutic  herb  dients.                        But  marijuana  may  be  MEDICINE                         vomiting,  pain,  disturbed
            worth more study.            Arizona-based  Insys  Ther-  helpful  in  reducing  use  of  The U.S. government grows  sleep, anxiety and depres-
            A look at the health claims  apeutics,  which  filed  for   opioid  painkillers.  The  Na-  marijuana for research at a  sion with few side effects.
            and  research  on  medical  bankruptcy       protection   tional  Center  for  Comple-  farm in Mississippi and gen-  Marijuana can ease many
            marijuana:                   Monday as it faced fallout   mentary  and  Integrative  erally  bans  grant-funded  symptoms “all at one time,”
            THE EVIDENCE                 over  its  marketing  of  an   Health,  better  known  for  studies  of  real-world  prod-  but more study is needed,
            Besides    chronic    pain,  addictive  opioid  painkiller,   its  research  on  herbs  and  ucts.                  said  study  co-author  Dr.
            there’s  strong  evidence  is  developing  CBD  drugs     yoga, has set aside $3 mil-  But  a  mobile  lab  inside  a  Dylan  Zylla  of  the  health
            marijuana  or  its  ingredi-  for two types of childhood   lion for studies to determine  white  Dodge  van  allows  care system HealthPartners.
            ents can ease nausea and  epilepsy and a rare genet-      which  of  marijuana’s  400-  University of Colorado Boul-  He  has  no  financial  ties  to
            vomiting  from  chemother-   ic  disorder.  Pennsylvania-  plus  chemicals  help  with  der  researchers  to  study  cannabis companies. Zylla
            apy  and  help  with  symp-  based  Zynerba  Pharma-      pain.                        the  potent  strains  of  mari-  is  studying  whether  can-
            toms of multiple sclerosis.  ceuticals  is  working  on  a   THC  was  excluded  how-  juana  many  patients  con-  cer patients can decrease
            Several  European  coun-     CBD  skin  patch  for  autism   ever.                     sume without running afoul  their prescription opioid use
            tries  have  approved  Sa-   and  fragile  X  syndrome,  a   Its  mood-altering  effects  of the law.               while using marijuana.
            tivex,  a  mouth  spray  con-  genetic condition.         and  potential  for  addic-  Study participants use mar-  Marijuana  “does  seem  to
            taining  THC  and  CBD,  for  Prescription  drugs  already   tion and abuse make it less  ijuana in their homes, com-  help  patients,”  he  said,
            multiple   sclerosis   symp-  on the market use synthet-  useful for pain, said Dr. Da-  ing  to  the  van  for  blood  “but  so  much  is  unknown
            toms.  Last  year,  U.S.  regu-  ic THC to treat weight loss,   vid  Shurtleff,  the  agency’s  draws  and  other  tests  be-  about the risks, side effects
            lators  approved  Epidiolex,  nausea and vomiting in pa-  deputy  director.  And  THC  fore  and  after  using,  said  and drug interactions.”q
                                                                      has  been  studied  more  Cinnamon Bidwell who has
                                                                      than the lesser-known com-   federal grants to study mar-
                                                                      pounds.                      ijuana’s  effects  on  lower
                                                                      CURE FOR CANCER?             back pain and anxiety.
                                                                      Despite    online   claims,  With  increased  demand
                                                                      there’s  only  weak  evi-    for  research  pot,  the  Drug
                                                                      dence  that  marijuana’s  Enforcement       Administra-
                                                                      ingredients  might  one  day  tion  created  an  applica-
                                                                      be  used  to  treat  cancer.  tion  process  for  growers,
                                                                      Most  studies  have  been  in  but has not acted on more
                                                                      animals  or  in  the  lab.  Re-  than  two  dozen  applica-
                                                                      sults have been mixed.       tions.
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