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A28    SCIENCE
                 Monday 19 noveMber 2018

            Next generation of biotech food heading for grocery stores




            By LAURAN NEERGAARD
             AP Medical Writer
            WASHINGTON  (AP)  —  The
            next  generation  of  bio-
            tech  food  is  headed  for
            the grocery aisles, and first
            up may be salad dressings
            or granola bars made with
            soybean  oil  genetically
            tweaked  to  be  good  for
            your heart.
            By early next year, the first
            foods  from  plants  or  ani-
            mals  that  had  their  DNA   Fred  Gmitter,  a  geneticist  at  the  University  of  Florida  Citrus   Fred  Gmitter,  a  geneticist  at  the  University  of  Florida  Citrus
            “edited”  are  expected  to   Research and Education Center, holds citrus seedlings that are   Research and Education Center, holds an orange affected by
            begin selling. It’s a different   used for gene editing research at the University of Florida in Lake   citrus greening disease at a grove in Fort Meade, Fla., on Sept.
            technology  than  today’s    Alfred, Fla., on Sept. 27, 2018.         Associated Press   27, 2018.                              Associated Press
            controversial  “genetically
            modified”  foods,  more  like   tion as it grows. Dairy cows   wild ancestor, but the gen-  instructions  from  naturally  to  DNA  that  could  affect
                                                                      erations  of  cross-breeding  hornless Angus beef cattle.
                                                                                                                                a  crop’s  nutritional  value
                                         that  don’t  need  to  under-
            faster breeding that prom-
            ises to boost nutrition, spur   go painful de-horning, and   made  them  more  fragile  “Precision   breeding,”   is  or an animal’s health, said
                                         pigs immune to a danger-
                                                                      and altered their nutrients.
                                                                                                                                Jennifer  Kuzma  of  the  Ge-
                                                                                                   how  animal  geneticist  Ali-
            crop  growth,  and  make
            farm  animals  hardier  and   ous  virus  that  can  sweep   GMOs, or genetically modi-  son  Van  Eenennaam  of  netic  Engineering  and  So-
                                         through herds.
                                                                      fied  organisms,  are  plants  the University of California,  ciety Center at North Caro-
            fruits  and  vegetables  last
            longer.                      Scientists even hope gene    or animals that were mixed  Davis, explains it. “This isn’t  lina State University.
                                                                      with another species’ DNA  going to replace traditional  Scientists  are  looking  for
                                         editing  eventually  could
            The U.S. National Academy
            of  Sciences  has  declared   save  species  from  being   to introduce a specific trait  breeding,” but make it eas-  any signs of problems. Take
                                                                                                   ier to add one more trait.
                                                                      — meaning they’re “trans-
                                         wiped  out  by  devastating
                                                                                                                                the hornless calves munch-
            gene  editing  one  of  the                               genic.”  Best  known  are  RULES AREN’T CLEAR
            breakthroughs  needed  to    diseases  like  citrus  green-  corn  and  soybeans  mixed  The  Agriculture  Depart-  ing in a UC-Davis field. One
                                         ing,  a  so  far  unstoppable
                                                                                                                                is  female  and  once  it  be-
            improve  food  production
            so  the  world  can  feed  bil-  infection  that’s  destroying   with  bacterial  genes  for  ment says extra rules aren’t  gins  producing  milk,  Van
                                                                      built-in  resistance  to  pests  needed  for  “plants  that  Eenennaam  will  test  how
                                         Florida’s famed oranges.
            lions  more  people  amid  a
            changing climate. Yet gov-   First  they  must  find  genes   or weed killers.         could otherwise have been  similar  that  milk’s  fat  and
                                                                                                   developed  through  tradi-
                                         that  could  make  a  new
                                                                      Despite international scien-
                                                                                                                                protein  composition  is  to
            ernments are wrestling with
            how  to  regulate  this  pow-  generation  of  trees  im-  tific  consensus  that  GMOs  tional  breeding,”  clearing  milk from unaltered cows.
                                                                      are safe to eat, some peo-
                                         mune.  “If  we  can  go  in
                                                                                                   the  way  for  development  “We’re kind of being overly
            erful  new  tool.  And  after
            years of confusion and ran-  and edit the gene, change    ple remain wary and there  of about two dozen gene-       cautious,”  she  said,  noting
                                         the DNA sequence ever so
                                                                      is concern they could spur  edited crops so far.
                                                                                                                                that if eating beef from nat-
            cor,  will  shoppers  accept
            gene-edited foods or view    slightly  by  one  or  two  let-  herbicide-resistant weeds.  In  contrast,  the  Food  and  urally hornless Angus cattle
                                         ters, potentially we’d have
                                                                      Now  gene-editing  tools,  Drug Administration in 2017  is fine, milk from edited Hol-
            them as GMOs in disguise?
            “If  the  consumer  sees  the   a  way  to  defeat  this  dis-  with  names  like  CRISPR  proposed  tighter,  drug-like  steins should be, too.
                                         ease,” said Fred Gmitter, a
                                                                                                   restrictions on gene-edited  But  to  Kuzma,  companies
                                                                      and TALENs, promise to al-
            benefit,  I  think  they’ll  em-
            brace  the  products  and    geneticist  at  the  University   ter  foods  more  precisely,  animals.  It  promises  guid-  will  have  to  be  up-front
                                                                      and  at  less  cost,  without  ance  sometime  next  year  about  how  these  new
                                         of  Florida  Citrus  Research
            worry  less  about  the  tech-
            nology,”  said  Dan  Voytas,   and   Education   Center,   necessarily  adding  foreign  on  exactly  how  it  will  pro-  foods  were  made  and
                                         as  he  examined  diseased
                                                                      DNA. Instead, they act like  ceed. Because of trade, in-
                                                                                                                                the  evidence  that  they’re
            a  University  of  Minnesota
            professor  and  chief  sci-  trees  in  a  grove  near  Fort   molecular  scissors  to  alter  ternational  regulations  are  healthy.  She  wants  regu-
                                                                      the letters of an organism’s  “the most important factor  lators  to  decide  case-by-
                                         Meade.
            ence officer for Calyxt Inc.,   GENETICALLY MODIFIED OR
            which  edited  soybeans  to   EDITED, WHAT’S THE DIFFER-  own genetic alphabet.        in  whether  genome  edit-   case  which  changes  are
                                                                                                                                no  big  deal,  and  which
                                                                      The  technology  can  insert  ing technologies are com-
            make the oil heart-healthy.  ENCE?
            Researchers  are  pursuing   Farmers  have  long  geneti-  new  DNA,  but  most  prod-  mercialized,”  USDA’s  Paul  might need more scrutiny.
                                                                      ucts in development so far  Spencer told a meeting of  “Most  gene-edited  plants
            more  ambitious  changes:
            Wheat with triple the usual   cally  manipulated  crops   switch off a gene, accord-   agriculture economists.      and  animals  are  probably
                                         and animals by selectively
                                                                                                                        court  going to be just fine to eat.
                                                                                                              highest
                                                                      ing to University of Missouri  Europe’s
            fiber,  or  that’s  low  in  glu-
            ten. Mushrooms that don’t    breeding  to  get  offspring   professor  Nicholas  Kalait-  ruled last summer that exist-  But you’re only going to do
                                                                                                   ing European curbs on the  yourself  a  disservice  in  the
                                                                      zandonakes.
                                         with certain traits. It’s time-
            brown, and better-produc-
            ing  tomatoes.  Drought-tol-  consuming  and  can  bring   Those  new  Calyxt  soy-    sale  of  transgenic  GMOs  long run if you hide behind
                                                                                                                                the  terminology,”  Kuzma
                                                                 to-
                                         trade-offs.
                                                                      beans? Voytas’ team inac-
                                                                                                   should  apply  to  gene-ed-
                                                      Modern
            erant  corn,  and  rice  that
            no longer absorbs soil pollu-  matoes,  for  example,  are   tivated  two  genes  so  the  ited  foods,  too.  But  at  the  said.
                                         larger  than  their  pea-sized   beans produce oil with no  World  Trade  Organization  AVOIDING A BACKLASH
                                                                      heart-damaging  trans  fat  this  month,  the  U.S.  joined  Uncertainty  about  regu-
                                                                      and that shares the famed  12  nations  including  Aus-   latory  and  consumer  re-
                                                                      health  profile  of  olive  oil  tralia,  Canada,  Argentina  action  is  creating  some
                                                                      without its distinct taste.  and  Brazil  in  urging  other  strange   bedfellows.   An
                                                                      The  hornless  calves?  Most  countries to adopt interna-  industry-backed  group  of
                                                                      dairy  Holsteins  grow  horns  tionally consistent, science-  food  makers  and  farmers
                                                                      that  are  removed  for  the  based  rules  for  gene-edit-  asked  university  research-
                                                                      safety of farmers and other  ed agriculture.              ers  and  consumer  advo-
                                                                      cows.  Recombinetics  Inc.  ARE THESE FOODS SAFE?         cates  to  help  craft  guide-
                                                                      swapped part of the gene  The  biggest  concern  is  lines  for  “responsible  use”
                                                                      that  makes  dairy  cows  what  are  called  off-target  of gene editing in the food
                                                                      grow  horns  with  the  DNA  edits, unintended changes  supply.q
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