Page 124 - LIBRO VITAMINA C

Anexo

1 (5%) from standard dose group. in haemoglobin and haematocrit were found
In order to guarantee comparability of the (p=0.002 and p= 0.016 respectively) only in
2 groups, homogeneity statistical analysis was the megadose Vitamin C group.
completed, with parametric and non parametric The return to normal of Haemoglobin and
tests according to each variable distribution. Haematocrit in the megadose group suggests
No adverse events were reported during that megadose Vitamin C treatment in smokers
the trial. improves tissue oxygenation.
From the results we want to highlight that The strengths of this study include:
in the Vitamin C megadose group there are • the size of the sample n = 46, superior
statistically significant differences between to previous studies on effectiveness of
measurements before intervention and the Vitamin C and smoking (n = 27) iii
measurement of day 17 in urinary Vitamin C, • It is about a random clinical double-
blood hemoglobin and blood Hematocrit; whilst blind study in patients who are smokers,
in standard dose group, there are significant homogeneous in variables such as: age,
differences only in urinary vitamin C. sex, weight, and the BMI, with an
In order to establish differences before additional control of intake of food rich
and after the intervention, an analysis with in Vitamin C by standardized dietary
Wilcoxon test for vitamin C level, Hemoglobin recommendations given to participants.
and C-LDL in the urine, T Test for related A weakness of the study could be
samples of Haematocrit were done. considered to be the determination of the
levels of Vitamin C by
using urine test strips,
Table 2 Comparison before and after GDE and GMD intervention
an indirect measure
of the plasma levels.
Variable/Group GDE n = 19 GMD n = 27 The ideal method
Vitamin C in Urine Z -3.3563 p = 0.000 Z -4.542 p = 0.000 is the measurement
Haematocrit T 1.364 p = 0.189 T 3.732 p = 0.001
Hemoglobin Z -0.260 p = 0.795 Z -2.416 p = 0.016 of Vitamin C in
C-LDL Z-0.201 p = 0.840 Z -0.432 p = 0.666 leukocytes, (Jacob et
al., 1987) 28, which
In the megadose group, actual haematocrit (p = 0.0001) and haemoglobin is not feasible in
(p = 0.016) have decreased significantly vs. the standard dose group. (The Colombia.
p value means that the original hypothesis that these values should have
decreased is probably true)
a. With the support of Universidad Del
Discussion Rosarioces Faculty of Medicine Department
This present study demonstrated statistically of Epidemiology
significant changes (p<0.05) in concentrations
of Vitamin C in urine (indirect measure of
the plasma concentrations) in standard dose
and megadose groups, measured before the References supplied on request and
intervention and on day 17 after the first IV available on <www.acnem.org>
dose. This change was significantly superior
(p>0.05) in the megadose group. In the
standard dose group, the measure changed from
26.79 ± 13.76 before the intervention to 39 ±
19.74 mg / 10 ml on day 17. In the megadose
group we found a change of 21.85 ± 11.9 to 71
± 20.6 mg / 10 ml after the intervention. These
results have not previously been reported in the
literature for smokers, which makes this study a
first approximation of this phenomenon.
The change in urinary concentrations of
Vitamin C in the standard dose group before
and after the intervention on day 17 of the
study (group that received the standard dose
and oral placebo) is statistically significant,
which makes us think that there is a lasting
effect, with time, of Vitamin C - even with
low dose IV. This raises the plasma level for
more than two weeks, which has previously
been documented . Nevertheless, this has
to be confirmed with additional studies. The
concentrations of hemoglobin and haematocrit
found to be increased above normal levels
in both groups at the start, were returned
to normal only in the megadose Vitamin C
group - statistically significant differences
3 - Journal of the Australasian College of Nutritional & Environmental Medicine - April 2008
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