Page 98 - Book of Abstracts 2020

8 Biannual Conference on Chemistry - CHEM 08
th

Synthesis, Antimicrobial, Anti-Cancer and
Molecular Docking of Two Novel Hitherto

Unreported Thiophenes
1
4
Y.N. Mabkhot, Nabila Abdelshafy Kheder, A. Barakat, M.I. Choudhary, S.
2
3
Yousuf and W. Frey
5
4
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid
2
University, Abha, KSA, Department of Chemistry, Faculty of Science, Cairo
University, Giza, Egypt, Department of Chemistry, Faculty of Science,
3
Alexandria University, Ibrahimia, Egyp, H.E.J. Research Institute of Chemistry,
4
International Center for Chemical and Biological Sciences, University of
Karachi, Pakistan, Institut für Organische Chemie, Universität Stuttgart,
5
Stuttgart, Germany. Email: nabdelshafy@sci.cu.edu.eg

ABSTRACT

One pot synthesis of two novel hitherto unreported thiophenes was
achieved by a facile and selective synthetic method. The crystal structures
of the synthesized compounds were determined using an X-ray single
crystal technique. The synthesized thiophenes were evaluated for their
anti-cancer and antimicrobial activities. Molecular docking studies of the
synthesized compounds were performed by (MOE). The predicted results
from the molecular docking studies were in complete agreement with the
experimental data for antimicrobial evaluation.

RO
H C O
3
O S O
2
RO OR i. PhNCS / K CO 3 O
O N S NH
O H C
3
1a,b ii. Cl Ph Ph
3a,b
3a: R=Et
3b: R= Me

BOOK OF ABSTRACTS CHEM 08 (2020) Page 97