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 A sketch of magnetotactic bacteria along with chain of magnetosomes inside them under SEM
the field of medicine. The various applications are medical imaging (MRI), targeted drug delivery, gene research and tumor hyperthermia. The most fascinating of them all is hyperthermia in which there is
controlled heating of magnetic nanoparticles (magnetosomes) on exposure to alternating magnetic field (AMF) to promote necrosis of tumor cells. This is just the time to use these magnetosomes as magnetic nanoparticles in Magnetic hyperthermia-mediated cancer therapy (MCHT) for treatment of Glioblastoma multiforme (GBM), a deadly brain tumor.
Glioblastoma: The deadly brain tumor
Glioblastoma multiforme, or GBM, is most aggressive of all the gliomas, the kind which inspires fear due its infiltrative and invasive malignant nature. Imagine if brain tumors were sharks, can you guess what would Glioblastoma multiforme or GBM be? Probably, bull sharks or Great Whites!
So, what is Glioblastoma multiforme? This deadly tumor or glioma is a Grade IV tumor, which means it is most malignant of all arising de novo without any grade precursor.
This tumor arises from brain cells called glial cells or their precursors within central nervous system. These tumors have got significant attention in scientific world as the survival rate of patients suffering from Glioblastoma is less than a year. The traditional treatment of such tumors involves surgery in combination with radiation therapy and chemotherapy, where drug Temozolomide (TMZ) accelerates the treatment process. Moreover, this notorious tumor has evaded
several attempts of innovative therapies due to its recurrent and malignant nature. However, scientific research has explored microRNA, gene therapy, virotherapy and intranasal therapy to find treatment of GBM and the current area of research interest is nano targeted drug delivery using magnetosomes,
Ms. Ankita Rathore || 225
    The discovery of these magnetotactic bacteria evoked a great scientific interest
in magnetosomes and its potential applications in the field of medicine. The various applications are medical imaging (MRI), targeted drug delivery, gene research and tumor hyperthermia.
  























































































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