Page 375 - AWSAR 2.0

by different routes but were thrown out. Fortunately, clathrin and caveolin acted as transportersand helped them to enter the cell. There began a continuous battle between SNPs and cancer cells, where
cancer cells used autophagy as a weapon, I explained.
Suddenly, Ajay asked, “Will you please elaborate regarding that part of the battle.”
I explained the mechanism
to him in simple words, I said, “
Ajay, in the process autophagy
initially (first 1 and 6 hours)
rescued cells from SNPs attack
with the help of lysosomes, but
with time (after 24 hours), the
nanoparticles overpower the
lysosomes, hence weakening
autophagic attack leading to
cell death. We also found that
in this battle, autophagy was also helping SNPs, inadvertently, by increasing their entry inside cancer cells. Just like Silver Surfer, initially helped Galactus against the Earth, but later on, he switched sides and turned
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against Galactus. Initially, upon entry of the nanoparticles, autophagy suppressed Reactive Oxygen Species (ROS), another main component of the battle making poor SNPs
inefficient, but over time as the number of SNPs increases inside the cell ROS kept on accumulating and destroyed the lysosomes, which were acting as the saviour of cancer cells. Thus, in this study, we unearthed the complicated relationship between autophagy and nanoparticles in cancer cells.”
Ajay, curious, asked, “Who won the battle ultimately, Galactus or Silver Surfer.
I replied, “The struggle is still on, and several people like me are working day in and day
out to find a way and defeat Galactus.”
Ajay seemed happy and satisfied, wishing me luck and said he will be more than happy todiscusstheprogressintheconcernedfield.
Cancer is a disease in which there is an uncontrollable growth of cells, commonly called a tumour, and these may or may not spread to other parts of the body. Just as Galactus feeds on one planet and then moves to another to deplete it of all its energy and resources, thus wiping it out of existence.