Page 490 - AWSAR 2.0

466 || AWSAR Awarded Popular Science Stories - 2019
two different binders competed for clustering by actomyosin asters, they organized into various spatial patterns based on how much they differed from each other in their binding strength and relative numbers. Our results suggested that this mechanism could help in understandingthespatiotemporalorganization and regulation of various processes on the cell surface, which in turn provided more insights into various diseases and their possible cures.
Studying a complex biological system such as the living cell surface demands an interdisciplinary approach. At Satyajit Mayor’s lab in NCBS, we employ a combination of cell- based experiments, in vitro reconstitution, quantitative microscopy and active collaboration with physicists at the Simons Centre, NCBS, to understand the underlying biophysical and biochemical principles of the cell membrane organization.