Page 19 - AC_Winter2019_online.indd
P. 19

help Oregon’s agricultural economy.   a different path through the intes-  His research team is working with
        One of these is a vaccine for Johne’s   tines where the immune system      sheep ranchers to evaluate a new
        Disease which affects both sheep      responds better,” says Bermudez.     vaccine.  It has already been used
        and dairy herds.                      “We know how to do it. The concept  successfully on a ranch in southwest
                                              has been proven, and we have         Oregon, and is now being tested on
        Johne’s disease is a contagious,      identified the antigens that produce   a larger operation. “It will be inter-
        chronic, and usually fatal infection   the antibodies, but it is not ready for  esting to see if the vaccine works on
        caused by a resistant species of      commercial use yet.”                 the second farm,” says Dr. Rockey.
        bacteria belonging to the same                                             “If so, it will open the door to a
        family as tuberculosis. In the U.S.   The Bermudez team has also created  better understanding of vaccines
        dairy industry alone, losses due to   a vaccine for bovine tubercu-        in sheep, and also provide infor-
        Johne’s disease are estimated at $250  losis. Although this disease is not   mation on protection against other
        million annually.                     common in the U.S., it is a problem   chlamydial diseases, including those
                                              in other countries and OSU has       in humans.”
        Dr. Bermudez’s research team is       obtained a patent to produce the
        working on a vaccine for Johne’s      vaccine commercially for sale        Getting The Right Nutrients
        disease. “The big problem with        overseas.
        Johne’s is that the offspring get                                          When cows, sheep or horses don’t
        infected very young by the mother’s   Sheep Ranchers Provide A Testing     get enough selenium (Se) in their
        infected milk,” says Bermudez, “and   Ground                               diet, it can contribute to a wide
        young animals, like young humans,                                          array of health problems including
        don’t have a mature immune system     Another professor, Dr. Dan Rockey,   muscular dystrophy and abnormal
        yet.”                                 is working on improving a vaccine    pregnancies. But selenium is a tricky
                                              for Chlamydia abortus, a common      nutrient for farmers to administer
        The vaccine they have developed       pathogen that causes spontaneous     because it can be toxic even in small
        can be given to the mothers, who      abortions in ewes. “There are        doses.
        then develop an antibody that is      commercial vaccines available, but
        passed on to their babies through     their utility is debatable, and some   Research by Dr. Jean Hall has found
        the milk. “The antibody binds to      actually cause abortions,” says Dr.   that fertilizing livestock hay with
        the Johne’s bacteria and directs it on  Rockey.                            selenium is a good way to prevent
                                                                                   Se-deficiency without causing
                                                                                   toxicity.


                                                                                   She has also collaborated with Dr.
                                                                                   Charles Estill, and others to demon-
                                                                                   strate that feeding recently-weaned
                                                                                   calves selenium-fertilized forage for
                                                                                   seven weeks increased their body
                                                                                   weight, whole-blood concentration,
                                                                                   and general good health.







                                                                             Professor Jean Hall supervises a student
                                                                             on her research team. They have shown
                                                                             that ferilizing hay with selenium improves
                                                                             animal health.

                                                                                        vetmed.oregonstate.edu  •   19
   14   15   16   17   18   19   20   21   22   23   24