Page 22 - IPCoSME 2021

1 INTERNATIONAL POSTGRADUATE CONFERENCE ON SCIENCE AND MARINE ENVIRONMENT 2021
st
(IPCoSME 2021)
“Environmental Sustainability Enhancement Through the Collaboration of Sciences”

RA-09

SERS-BASED BIOSENSING WITH NOBLE METAL NANOPARTICLES FOR
APPLICATION IN VIRUS DETECTION

1
1
CHAN KIKI , NURUL HUDA ABDUL KADIR AND SYARA KASSIM 1,2*

1 Faculty of Science and Marine Environment, Universiti Malaysia Terengganu, Malaysia
2 Advanced Nano Materials Research Group (ANoMa), Faculty of Science and Marine
Environment, Universiti Malaysia Terengganu, Malaysia

*Corresponding author email: syara.kassim@umt.edu.my

Abstract: Viral infections pose a looming threat worldwide that could result in the detriment

of every nation and individual’s well-being as they can be difficult to detect and even harder
to treat. Quick and accurate detection is crucial in containing viral outbreak to avoid a

pandemic, especially when it pertains to a highly infectious novel strain of virus that faces rapid

mutation. Surface-enhanced Raman spectroscopy is a simple, affordable, and robust analytical
technique that is capable of providing a fingerprint of an analyte down to a single molecule. It

emerges as a promising analytical detection method and much attention has been turned
towards its potential in point-of-care diagnosis of virus infection. In this work, a review of

recent advancements in trends of SERS-based biosensing strategies for virus detection is
presented. The possible factors affecting the diagnostic performance of SERS in regards to

virus biosensing are discussed, along with a highlight of prospects and present challenges in

SERS and biosensing technologies. This review aims to serve as a quick overview to
developing future strategies in outbreak prevention and management, and aid in the

advancement of SERS-based viral sensing devices. The current trend of nanobiosensing
appears to be heading towards real-time monitoring of disease progression in the form of point-

of-care microdevices and building a potential database of spectral data from SERS fingerprints

of viruses for quick identification and detection. SERS sensing faces challenges in terms of the
lack of a standard and validated technique of design and fabrication. The methods to fabricate

some excellent SERS sensing schemes required a cost that is greater than the conventional
methods, hindering it from surpassing methods such as ELISA despite the many advantages

over it.

Keywords: SERS, virus, biosensors, nanoparticle, Raman

22