Page 38 - ASME IMECE 2018 Program

TRACK PLENARY
Track 4: Biomedical and Biotechnology
Engineering
4-1-1: BIOMEDICAL AND BIOTECHNOLOGY PLENARY I
Wednesday, November 14, 9:00am–9:45am
Room 303, David L. Lawrence Convention Center
Acoustofluidics: Merging Acoustics and Microfluidics for
Biomedical Applications
(IMECE2018-90094)
Tony Jun Huang
Duke University
Abstract: The past two decades have witnessed an explosion
in lab-on-a-chip research with applications in biology,
chemistry, and medicine. The continuous fusion of novel
properties of physics into microfluidic environments has
enabled the rapid development of this field. Recently, a new
lab-on-a-chip frontier has emerged, joining acoustics with
microfluidics, termed acoustofluidics. Here we summarize our
recent progress in this exciting field and show the depth and
breadth of acoustofluidic tools for biomedical applications
through many unique examples, from exosome separation to
cell-cell communications to 3D bioprinting, from circulating
tumor cell isolation and detection to ultra-high-throughput
blood cell separation for therapeutics, and from high-precision
micro-flow cytometry to portable yet powerful fluid
manipulation systems. These acoustofluidic technologies are
capable of delivering high-precision, high-throughput, and
high-efficiency cell/particle/fluid manipulation in a simple,
inexpensive, cell-phone-sized device. More importantly, the
acoustic power intensity and frequency used in these
acoustofluidic devices are in a similar range as those used in
ultrasonic imaging, which has proven to be extremely safe for
health monitoring during various stages of pregnancy. As a
result, these methods are extremely biocompatible; i.e., cells
and other biospecimen can maintain their natural states
without any adverse effects from the acoustic manipulation
process. With these unique advantages, acoustofluidic
technologies meet a crucial need for highly accurate and
amenable disease diagnosis (e.g., early cancer detection and
monitoring of prenatal health) as well as effective therapy (e.g.,
transfusion and immunotherapy).
xxxvi Bio: Tony Jun Huang is William Bevan
Professor of Mechanical Engineering and
Materials Science at Duke University.
Previously, he was a Professor and The Huck
Distinguished Chair in Bioengineering Science Biomedical Engineering of Mayo Clinic College of Medicine in
and Mechanics at The Pennsylvania State
University. He received his Ph.D. in Mechanical and Aerospace
Engineering from the University of California, Los Angeles
(UCLA) in 2005. His research interests are in the fields of
acoustofluidics, optofluidics, and micro/nano systems for
biomedical diagnostics and therapeutics. He has authored/
co-authored over 190 peer-reviewed journal publications in
these fields. His journal articles have been cited more than
11,000 times, as documented at Google Scholar (h-index: 59).
He also has 20 patents and invention disclosures. He was
elected a fellow of the following five professional societies:
the American Institute for Medical and Biological Engineering
(AIMBE), the American Society of Mechanical Engineers (ASME),
the Institute of Electrical and Electronics Engineers (IEEE), the
Institute of Physics (IOP), and the Royal Society of Chemistry
(RSC). Huang’s research has gained international recognition
through numerous prestigious awards and honors, including
a 2010 National Institutes of Health (NIH) Director’s New
Innovator Award; a 2012 Outstanding Young Manufacturing
Engineer Award from the Society for Manufacturing Engineering;
a 2013 American Asthma Foundation (AAF) Scholar Award;
JALA Top Ten Breakthroughs of the Year Award in 2011, 2013,
and 2016; the 2014 IEEE Sensors Council Technical Achievement
Award from the Institute of Electrical and Electronics Engineers
(IEEE); and the 2017 Analytical Chemistry Young Innovator
Award from the American Chemical Society (ACS).
Track 4: Biomedical and Biotechnology
Engineering
4-1-2: BIOMEDICAL AND BIOTECHNOLOGY PLENARY II
Wednesday, November 14, 8:00am–8:45am
Room 304, David L. Lawrence Convention Center
New Directions in Medical Ultrasound
(IMECE2018-90095)
Dr. Mostafa Fatemi
Mayo Clinic
Abstract: Traditional diagnostic ultrasound has evolved from a
simple anatomical imaging tool to a sophisticated technology
that involves quantifying tissue properties and function from
molecular level to the organ level. Many disease processes
cause microscopic changes in tissue that may include
alteration of a tissue’s mechanical properties and, in some
cases, changes in microvasculature network. Ultrasonic
methods for measuring such changes in the human body are
of great interest. The fact that ultrasound is noninvasive and
capable of making measurements at sufficient depths in the
body makes this technology a prime candidate for developing
new diagnostic tools. This talk will cover some new
methodologies in medical ultrasound, including novel methods
in estimating tissue viscoelasticity and new techniques for
imaging microvasculature networks with high definition and
studying their architecture in the targeted tissue.
Bio: Mostafa Fatemi received his Ph.D. in Electrical Engineering
from Purdue University. Currently, he is a Professor of
Biomedical Engineering at the Department of Physiology and
Rochester, MN. At the Mayo Clinic, he is also a member of the
Mayo Clinic Cancer Center, Cancer Imaging Program, and the
Center for Clinical and Translational Science. In addition, he is
a Professor of the Biomedical Informatics and Computational
Biology graduate program at the University of Minnesota
Rochester. Dr. Fatemi’s current research areas include
ultrasonic methods for tissue viscoelasticity estimation and its
applications in cancer imaging and bladder function evaluation.
His past and current research activities have been funded by
the National Institutes of Health, National Science Foundation,
Department of Defense Medical Research Program, Komen