Page 11 - CPG - Clinical Practice Guidelines - Management of Cancer Pain
P. 11
Management of Cancer Pain (Second Edition)
• WHO Guidelines on the Pharmacological Treatment of Persisting
Pain in Children with Medical Illness 2012
A total of 23 main clinical questions were developed under different
sections. Members of the DG were assigned individual questions within
these sections. Refer to Appendix 2 for Clinical Questions. The DG
members met 24 times throughout the development of these guidelines.
All literature retrieved was appraised by at least two DG members using
the Critical Appraisal Skill Programme checklist, presented in evidence
tables and further discussed in each DG meeting. All statements and
recommendations formulated after that were agreed upon by both the
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the recommendations were made by consensus of the DG and RC. Any
differences in opinion are resolved consensually. The CPG was mainly
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trials, with local practices considered.
The literature used in these guidelines was graded using the US/
Canadian Preventive Services Task Force Level of Evidence (2001)
while the recommendation grading was done using GRADE principles
(refer to the preceding page). The writing of the CPG follows strictly
the requirement of Appraisal of Guidelines for Research and Evaluation
(AGREE II).
On completion, the draft CPG was reviewed by external reviewers. It
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Advisory Committee for CPG and, the Health Technology Assessment
(HTA) and CPG Council, MoH Malaysia, for review and approval.
Details on the CPG development by MaHTAS can be obtained from
the Manual on Development and Implementation of Evidence-
based Clinical Practice Guidelines published in 2015 (available at
https://www.moh.gov.my/moh/resources/CPG_MANUAL_MAHTAS.pdf).
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