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Initiation of combination antihypertensive therapy better

catch-up blood pressure target versus monotherapy

Several mechanisms of increased blood pressure blockage

Complementary/synergistic vasculo-protective effects

Less dose-dependent adverse effects

Complementary/synergistic vasculo-protective effects

Avoidance of dose-dependent adverse effects is seen with
higher doses of single agents

Reduction in heterogeneity of blood pressure response between

patients

Greater reductions in blood pressure figures

Higher number of patients reach individual blood pressure goals
with SPC

Blood pressure goal achievement in a shorter time, with fewer
titration steps

Greater protection to target organs

Better medication adherence and persistence

Drugs in Context 2018; 7: 212531