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Time to achieve blood pressure goal is key

determinant for clinical outcome

!

Greater cumulative
Longer exposure Higher risk of target
to higher BP cardiovascular risk organ damage
exposure.

The most effective strategies to achieve BP control in shorter time:

Combination therapy in most patients*, especially in the
context of lower BP targets.

Single pill combination (SPC) versus free equivalent
1 Pill combination (FEC) as first-line treatment for most patients,

helps to achieve early and sustained blood pressure control.

24 hrs 1 Pill Once-daily regimen for better adherence and greater

persistence.

Single pill combination therapy simplifies treatment and
1 Pill
optimizes long-term compliance versus free combination.

*except in age ≥ 80y/o, frailer , low risk grade 1 (calculated 10 y SCORE of <1% and without any risk factor, disease and HMOD).
Eur Heart J. 2018 ;39:3021-3104, Hypertension. 2020;75:1334-1357, J Hypertense. 2018;36:1953-2041, Int J Cardiol. 2018;254:328-332.