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Higher efficacy, shorter time-to-goal and better
tolerability with single pill combination vs.
monotherapy
Single-pill
Low-dose High-dose
monotherapy monotherapy combination
therapy
Efficacy - + ++
Time to reach - + ++
BP target
BP variability - - +
Simplicity + + +
Compliance + + +
Tolerability + - ++
Comparison between different HTN management strategies
Adapted from Integr Blood Press Control. 2013; 6:69-78, Hypertension. 2021;77:692–705
