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Simplicity, better compliance and tolerability

all together with single pill combination

versus free combination

Single-pill
Low-dose tion
Free c ombina combination
High-dose
monotherapy monotherapy
y
ap
ther
therapy
-
+
Efficacy
Efficacy ++ ++
-
Time to reach BP ++ ++
+
Time to reach BP
target
target
-
-
BP variability
BP variability + +
-
+
Simplicity + +
Simplicity
-
+
Compliance + +
Compliance
-
+
Tolerability + ++
Tolerability

Comparison between different HTN management strategies

Adapted from Integr Blood Press Control. 2013; 6:69-78, Hypertension. 2021;77:692–705