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Combination of ARB with CCB or diuretic are recommended

single pill combination components by guidelines

The 2018 ESC/ESH guidelines recommend the combination of a drug that blocks
the renin-angiotensin system (RAS) with a calcium channel blocker (CCB) or a
thiazide/thiazide-like diuretic.

Decide which single pill combination to choose based on:

- Individual patient characteristics and comorbidities

- HMOD findings

ARBs are better tolerated than ACEIs due to:

- ACEI-related cough.

- Angioedema with ACEIs.

CCBs:

- Suggest better results in patients with ischemic heart disease in combination

with RASI.

- Are among preferred component of SPC with RASIs, especially in hypertensive
patients with an increased risk of diabetes.

Diuretics:

- Are among recommended choices for lowering BP and reducing recurrent
stroke risk, in patients with hypertension who experienced a stroke or TIA

- Are more effective than other hypersensitive drug classes in preventing heart failure.

Curr Med Res Opin. 2019; 35:113–115, Hypertension. 2020; 75:1334-1357, Hypertension. 2018; 71:e13-e115, Stroke. 2021;52:e364- e467.