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Time in therapeutic range has inverse relation with

all-cause mortality in patients with hypertension

1.00

% of SBP readings
in therapeutic range
0.95
≤ 25%

> 25 - 50%
0.90
> 50 - 75%
Survival estimate 0.85 > 75 - 100%

0.80

0.75

0.70
0 10 20 30 40 50 60 70 80 90 100 110 120

Months from third elevated BP

Cox regression models: mortality rates for patients with systolic BP measurements in therapeutic range
0% to 25%, 25% to 50%, 50% to 75%, or >75% of BP measurements. Follow-up to 120 mo.

A total of 689 051 individuals were followed over a 10-year period. Time within, above, or below therapeutic range (120–140 mm Hg)
was considered in quartiles and related to all-cause mortality.

J Am Heart Assoc. 2017;6:e007131, PloS One. 2018 ;13:e0202359. J Am Coll Cardiol 2021;77:1290–299