Page 40 - Annual report 2021-22
P. 40
Annual Report 2021-22 |
antichymotrypsin, gelsolin, alpha-2- hs-glycoprotein, and serum amyloid a-1 proteins showed
significant difference between severe and control groups. Plasma MRM for these proteins in 231
samples from 18 healthy controls, 13 severe and 68 mild/moderate COVID patients with follow-up
samples at 2 different time points revealed that albumin, haptoglobin, alpha-1- anti-chymotrypsin,
transthyretin and leucine-rich alpha-2-glycoprotein show significant dysregulation at day 1 between
control and severe group and mild group. Targeted lipidomic analysis revealed upregulated levels of 23
triglycerides. Shantanu Sengupta has also spearheaded the establishment of a cohort of CSIR-IGIB
personnel and their family for long term follow-up of health and disease outcomes. During the
COVID19 pandemic, this cohort was utilized for understanding viral exposure and vaccine efficacy. In
addition, serosurveillance was performed in a cohort of healthcare workers from which breakthrough
infection rate and vaccine effectiveness was estimated.
“All of physics is either impossible or trivial. It is impossible until you
understand it, and then it becomes trivial.” — Ernest Rutherford
