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Annual Report 2021-22 |
were characterized. Molecular phenotypic assignment was carried out 38 culture-positive isolates to
identify the prevalent pathogens; Rhizopus spp. was identified as the primary pathogenic agent
responsible for ~58% of all cases (~47% R. arrhizus/ R.oryzae + ~11% R. microsporus) followed
by Aspergillus fumigatus (26% cases). Whole genome sequencing-based phylogenomics analysis
identified distinct clusters within Rhizopus spp., suggesting prevalence of multiple strains. However,
antifungal susceptibility tests with several antifungal agents, namely, amphotericin B, ciclopirox, 82
itrconazole, ketoconazole and nikkomycin indicated that all strains exhibited sensitivity to the tested
agents similar to ATCC strains, suggesting that any of the major therapeutic agents could be used
against these fungi for treatment.
“Technical skill is mastery of complexity while creativity is mastery of
simplicity.” ― E. C. Zeeman
