Page 42 - CSIR-IGIB Annual Report 2020-21

pulmonary fibrosis are manifested as hallmarks Karyakram (RPPK)’ under the aegis of
of severity in COVID-19 patients. We further AYUSHMAN Bharat towards implementation of
determined if the AV extract directly inhibits Ayurveda in public health and Promotion of
SARS-CoV2 replication, using in vitro cultures. Prakriti based Health and Wellness
Docking studies identified specific chemical recommendations. Ayurveda physicians from
constituents of AV to have binding affinity for AYUSH Health and Wellness Centers were
viral and host proteins. Clinical trial studies for trained for Prakriti and lifestyle Analysis to be
evaluating the effects of AV on SARS-CoV2 able to advise personalised lifestyle
positive subjects with mild symptoms have been modifications as per Prakriti.
initiated in collaboration with All India Institute
of Ayurveda (AIIA) with approval from the Information, education and communication
Ministry of AYUSH. activities
Nationwide Training of Ayurveda Faculty from
Another plant described in Ayurveda, government and private institutions will equip
Cissampelous pareira (CIPA), is reported to have them to participate and steer Research and
multiple pharmacological activities and finds Development activities at AYUSH institutions
diverse therapeutic applications in fever and and inter-disciplinary collaborative research.
female hormonal diseases. We studied Faculty can also be sensitized for directly
transcriptomic signatures in MCF7 cell line bringing in the novel knowledge of
treated with CIPA and identified biological links Ayurgenomics as an integrative discipline to
between estrogen and anti-dengue activity Undergraduate and Post graduate teaching
using connectivity map-based analysis of settings. Training of MD/ Ph.D Students from
transcriptomic signatures. SARS-CoV2 viral collaborating institutions such as, AIIMS and
inhibition in a cell culture model was also AIIA , with an aim to create human resource
observed, highlighting its potential for rooted in knowledge of Ayurveda fundamentals
repurposing in COVID-19 disease. The studies and Prakriti applications was carried out.
are done in collaboration with scientists who Besides MD and PhD courses, creation of novel
are experts in diverse disciplines at IGIB, and curriculum and courses for Ayurveda Biology at
CSIR as well as DBT institutions. JNU, DU and other academic institutions help in
integrative medical research. At CoE workshops
Capacity building in Ayurgenomics & Prakriti our group has conducted brainstorming
Methods sessions & panel discussions on Ayurveda and
Under the Centre of Excellence (CoE) for Applied integrative medicine with stakeholders
Development of Ayurveda Prakriti and representing modern medicine, clinicians,
Genomics’ our group has undertaken training integrative practitioners, Ayurveda experts and
programs and outreach activities with a multi- teaching faculty for enabling networking among
pronged approach. We have conducted a integrative research & healthcare community.
nationwide training program involving AYUSH More such outreach activities for creating inter-
Officers, Community Health Officers and field disciplinary human resources for integrated
workers in “Prakriti Parikshan Methods”, as an health research are being planned for the
activity of ‘Rashtriya Prakriti Parikshan future.

Publications
Frequency spectrum of rare and clinically relevant markers in multiethnic Indian populations (ClinIndb): A resource
for genomic medicine in India. Narang A, Uppilli B, Vivekanand A, Naushin S, Yadav A, Singhal K, Shamim U, Sharma
P, Zahra S, Mathur A, Seth M, Parveen S, Vats A, Hillman S, Dolma P, Varma B, Jain V; TRISUTRA Ayurgenomics
Consortium, Prasher B, Sengupta S, Mukerji M, Faruq M. Hum Mutat. 2020 Nov;41(11):1833-1847.

Annual Report 2020-21 39