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International Conference on

Recent Trends in Environmental Sustainability

ESCON22/ETERM/07
Elucidating hypoglycemic and hypolipidemic effect of microwave assisted Cymbopogan
citratus extracts using animal model

Mavra Javed
Correspondence: javedmavra@gmail.com

Abstract
Cymbopogan citratus,commonly known as lemon grass, is an astonishing plant. In this study,
bio-efficacy of hypoglycemic and hypolipidemic potential of lemon grass extracts obtained by
microwave assisted extraction (MAE) technology was assessed using animal model. Lemon
grass extract was obtained after optimization of conditions, extract was obtained at 900W
power,with 5:1 solvent to plant material ratio in 20mins at 70⁰C. For bio-efficacy trial, 30
female rats were purchased and kept under standard conditions. They were divided into 2
studies comprising 3 groups each i.e. normal, negative control and positive control. Daily feed
and water intake and weekl weight change was recorded. Diabetes was induced by high sucrose
diet and dyslipidemia by high fat diet. Biochemical analysis was carried out at the start and end
of trial. Positive control group of study I was fed with 5ml lemon grass extract for 28 days
along with basal diet whereas in study II positive control group was fed for 42 days with 5ml
extract. Results revealed that mean blood sugar levels of positive control group decreased
significantly (p≤0.05) in study I whereas lipid profile was also improved significantly in study
II. It is concluded that Cymbopogan citratus extracts areeffective against diabetes mellitus.
Keywords: Lemon grass, microwave assisted extraction, hypolipidemia, hypoglycemic

Department of Environmental Sciences, COMSATS University Islamabad, Vehari Campus

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