Page 18 - Microbiology in workplace
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GMP Training – Microbiology in the Workplace by www.gmpsop.com
Tablets/Capsules
E. coli People, Water
Staphylococcus aureus People
Salmonella sp. Raw Materials
Minimizing microbes
We cannot eliminate micro-organisms. But we can minimize their numbers, or
exclude them from our manufacturing following lists a number of methods we
use to minimize micro-organisms:
Control the manufacturing environment
Wear protective clothing
Implement cleaning and sanitation programs
Keep equipment clean and dry
Maintain room pressures by keeping doors closed
Maintain a high standard of personal hygiene
Critical microbial control issues
The challenge to the industry is to minimize or, as with sterile products, totally
exclude or destroy micro-organisms from the products being manufactured.
Critical microbial control issues arise during different stages of the
manufacturing process.
These issues can arise in:
Starting materials control
Production equipment control
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