Page 103 - Physiology and Pathophysiology MNU 2024-2025 نظرى

Clinical pharmacy 2024/2025 Level 2 Pharm D Physiology and Pathophysiology (MD303)
Glomerular Filtration Membrane

Endothelial capillary pores are large fenestrae.

100-400 times more permeable to plasma, H2O, and dissolved solutes

than capillaries of skeletal muscles.

Pores are small enough ➔ to prevent RBCs, platelets, and WBCs from
passing through the pores.

▪ Filtrate must pass through the basement membrane:

 (Thin glycoprotein layer-Negatively charged)

• Podocytes:
✓ Foot pedicels form small filtration slits.

✓ Passageway through which filtered molecules must pass.

Glomerular Ultrafiltration

ultrafiltrate Glomerular filtration • Glomerular filtration rate (GFR):
Fluid that enters glomerular - Mechanism of producing ultrafiltrate under hydrostatic - Volume of filtrate produced by both kidneys each
capsule pressure of the blood. minute.

- Process similar to the formation of tissue fluid by other - Averages 115 ml/min. in women.
capillary beds. - 125 ml/min. in men.

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