Page 100 - Physiology and Pathophysiology MNU 2024-2025 نظرى

Clinical pharmacy 2024/2025 Level 2 Pharm D Physiology and Pathophysiology (MD303)
Glomerular Capsule Proximal convoluted tubule (PCT)

▪ Bowman's capsule: ✓ Single layer of cuboidal cells with millions of microvilli.

(Surrounds the glomerulus -Location where glomerular filtration occurs.)   surface area for reabsorption.

• Filtrate passes into the urinary space into proximal convoluted tubule • PCT functions:
(PCT). ▪ Reabsorption. - Secretion.

Loop of Henle Distal Convoluted Tubule

• Fluid passes from proximal convoluted tubule (PCT) to loop of Henle (LH). • Contains a few microvilli.

▪ Descending limb ➔ H2O reabsorption. ▪ Functions: [Secretion-Reabsorption]
• Ascending limb: Active transport of Na+. Impermeable to H2O. • Terminates in collecting duct (CD).

Collecting Duct

• Receives fluid from the distal convoluted tubules (DCT) of several • Functions:
nephrons. 1. Reabsorption.

• Passes through renal pyramid into minor calyx. 2. H2O reabsorption influenced by anti-diuretic hormone (ADH).

3. Secretion.

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