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Clinical pharmacy 2024/2025 Level 3 Pharm D Pharmacology 1 (PO 502)

4- Volanesorsen

Apo C-III Synthesis inhibitors:
➢ Apo C-III: inhibits LPL ➔ reduced lipolysis of TG rich lipoproteins TG

➢ Apo C-III: Inhibits hepatic lipase➔ reduced catabolism and uptake of TG rich
lipoprotein remnants
➢ Uses: hypertriglyceridemia, familial chylomicronemia syndrome

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