Page 75 - phytochemistry general program

Clavine type ergot alkaloids
B - The lysergic acid amides; and these are amide alkaloids that are derived from

lysergic acid.

Lysergic acid amides
Again this amide alkaloids class can be further distinguished into two subclasses:

i- The simple lysergic acid amides; that are built up of lysergic acid and a
. simple amine

ii- The polypeptide alkaloids; that are complex amides of lysergic acid with
. several (three) different amino acids
The clavine alkaloids .1

clavine), e.g. –names of the alkaloids of this class all end in ( The
agroclavine, elemoclavine and penniclavine….etc.

They are all simple water-soluble bases. They are not as physiologically
active as the lysergic acid derivatives, so they are of little medicinal value. Few
examples have been shown recently to have significant ecbolic (oxytocic) activity.

Examples of clavine alkaloids

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