Page 64 - Phytochemistry 2 (06-PG 605)

Tropane alkaloids

Tropane alkaloids are a well recognized group of structurally
related natural products. The tropane alkaloids occur mainly in the
plant family Solanaceae. Tropane alkaloids are ester alkaloids
which on hydrolysis yield an organic acid and an amino alcohol as
a base. Tropane, consists of seven membered bicyclic ring with a
nitrogenous bridge between C1 & C5.

Me

N1 2

5 4 3H
67 H

Tropane nucleus

The major tropane alkaloids of pharmacological and

therapeutic importance can be classified into two main groups.

I- Solanaceous tropane alkaloids.

II- Coca alkaloids.

I- Solanaceous tropane alkaloids

The term solanaceous alkaloids is generally restricted to the

alkaloids of the tropane nucleus. Because of their mydriatic effect,

the tropane solanaceous alkaloids are also referred to as

“mydriatic alkaloids”.

Plant source

The most important solanaceous plants that contain tropane
alkaloids are species of the genera, Atropa, Datura, Hyoscyamus.

Hyoscyamine, atropine and scopolamine are among the

pharmacologically important alkaloids of this class, beside several

other alkaloids that are chemically related to these alkaloids.

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