Page 130 - Biochemistry2 (08PB403)
P. 130

Uses of NADPH

IJ. Reductive biosynthesis
       NADPH is a high energy molecule and electron donor. It is
       required as a source of electrons for biosynthesis of FA,
       cholesterol, sterols, hormones, and bile salts.

Ĵ. Reduction of H2O2: ROS-damage DNA, proteins, unsaturated
       lipids– reperfusion injuries, cancer, inflammatory diseases,
       aging.

Enzymes that catalyze Antioxidant reactions

       Glutathione peroxidase or GOD [using reduced Glutathione or
       GSH which is active as antioxidant, present in most cells which
       can detoxify H2O2 ].

       Glutathione reductase or GR [regenerates GSH from oxidized
       glutathione formed in the above reaction] using NADPH as a
       source of electrons.

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