Page 4 - Pharmaceutics-II (02-06-01 203)

Semi solids in cosmetic preparations ...........................................................................36
Transdermal drug delivery systems ................................................................................39
1. Skin structure ...........................................................................................................39

Skin functions ...........................................................................................................39
2. Definition of TDDS ................................................................................................40
3. Rational approach to drug delivery to and via the skin .............................................40
4. Advantages of TDDS ..............................................................................................41
Disadvantages of TDDS .............................................................................................41
5. Factors affecting permeation of transdermal drug delivery .......................................41
6. Criteria for selection of drug candidate for TDDS ....................................................43
7. Drug transport through the skin &routes of penetration pathways of drug penetration
................................................................................................................................44
8. Maximizing the bioavailability of drug applied to the skin ........................................46
Formulation of Transdermal drug delivery systems (TDDs) .............................................51
Intended learning outcomes .......................................................................................51
Recommended references...........................................................................................51
Difference between topical and transdermal drug delivery system (TDDs).....................51
Types of TDDSs:........................................................................................................52
Transdermal delivery patches: ...................................................................................54
Basic components of transdermal drug delivery...........................................................54
Formulation considerations and components of TDDs..................................................54
Innovative strategies for TDDs ...................................................................................59
Transdermal patches manufacturing process...............................................................60
Selected examples of marketed transdermal patches ....................................................61
Evaluation of Transdermal patches.............................................................................65

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