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Formulation of Transdermal drug delivery systems (TDDs)

Intended learning outcomes

▪ Definition.
▪ Formulation considerations and components of TDDs.
▪ Designs of transdermal patches.
▪ Innovative strategies for TDDs.
▪ Transdermal patches manufacturing process.
▪ Selected examples of marketed TDDs.
▪ Evaluation of TDDs.

Recommended references

• Ansel’s pharmaceutical dosage forms and drug delivery systems, Eleventh Ed., Lippincott
Williams & Wilkins, 2017.

• Pharmaceutics: The Science of Dosage Form Design by Michael Aulton.
• Transdermal and Topical Drug Delivery: Principles and Practice by Heather A.E. Benson,

Adam C. Watkinson, 2012.

Difference between topical and transdermal drug delivery system (TDDs)

Topical
• Designed to deliver the drug into the skin to treat dermal disorders (Skin is the target organ)

Transdermal
• Designed to deliver the drug through the skin into the general circulation for systemic effects
(Skin is not the target organ)

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