Page 113 - phytochemistry II -pharmD general

Antioxidants free radicals can also react with lipid free radicals to form a
stable complex compound thereby preventing some of their damages. Thus,
two principal mechanisms of action have been proposed for antioxidants, a
chain-breaking mechanism by which the primary antioxidants donate
electrons to the free radicals present in the system and another mechanism
involves removal of ROS (reactive oxygen species) and RNS (reactive
nitrogen species) initiator by quenching chain initiator catalyst.
Flavonoids as antioxidants
Flavonoids inhibit "in vitro" oxidation of LDL and their cytotoxicity. in humans
consumption of flavonoids appears to be related to a reduction of the risk of
cardiovascular diseases. Most flavonoids inhibited the ox-LDL-induced ROS
generation. Flavonoids as a dietary supplement prevents atherosclerosis in
patients at risk of coronary artery disease.

Potential effects of flavonoids on cardiovascular protection.

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