Page 73 - phytochemistry II -pharmD general

Again this amide alkaloids class can be further distinguished into two
subclasses:

i- The simple lysergic acid amides; that are built up of lysergic acid and
a simple amine.

ii- The polypeptide alkaloids; that are complex amides of lysergic acid with
several (three) different amino acids.

a. The clavine alkaloids
The names of the alkaloids of this class all end in ( –clavine), e.g.
agroclavine, elemoclavine and penniclavine….etc.

They are all simple water-soluble bases. They are not as physiologically
active as the lysergic acid derivatives, so they are of little medicinal value. Few
examples have been shown recently to have significant ecbolic (oxytocic) activity.

Examples of clavine alkaloids

HOH2C H3C H3C
NH
NCH3 NCH3

NH NH NH

Elymoclavine Festaclavine Agroclavine

HOH2C OH HO
HOH2C

NCH3

NH NH

Chanoclavine Penniclavine

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