Page 17 - Quality control of pharmaceuticals (07-PA 704)

Flow rate (pump)
Injection volume (injector)
Column temp (oven)
Detector linearity (detector)

Qualification of UV/Vis Spectrophotometers
The essential parts of spectrophotometer:
Source of light, dispersion device, sample holder and detector and meter
Specifications of Spectrophotometer:
λ-accuracy.
Absorbance accuracy.
Stray light.
Noise (baseline Flatness).
Pharmacopoeial standards.

Calibration of pH Meter
The pH-meter is an apparatus used to measure [ H+ ] of solutions by

measuring the potential between 2 electrodes immersed in the
solution of unknown pH.
The pH meter can be calibrated using 3 buffer solutions:
-Standard Buffer 1 pH 4.00