Page 113 - Clinical Biochemistry

Triglycerides TG:
• Triglyceride is body storage form of fat and energy. Most TG found in adipose tissue.
• Give energy in case of absence of carbohydrates. Some triglycerides circulate in the blood to
provide fuel for muscles to work.
• Extra triglycerides are found in the blood after meal.
• Elevated in obese or diabetic patients. Level increases from eating simple sugars or drinking
alcohol. Associated with heart and blood vessel disease.

TG levels:

TG test needs 12 hrs fasting because its level is affected by meal (fatty meal, high carbohydrates
meal). Level should be: Less than 150 mg/dl. High TG leads to fatty liver .

Laboratory test for lipid profile

TC, HDLC, LDLC, TAG

Case Study-1

A 64-year old woman ispresent at the Accident and Emergency department with severe chest
pain which had been present for the past hour. He had previously attended the chest pain clinic
and had a 2 year history of angina of effort.

What specific test would you request from the biochemistry laboratory?

Case Study-2

60 year-old man had experienced central chest pain on exertion for some months but in the
afternoon of the day prior to admission he had had a particularly severe episode of the pain
which came on without any exertion and lasted for about an hour. On admission there were no
abnormalities on examination and the ECG was normal, the troponin was clearly detectable

Comment on these results. Has he suffered an MI?

Objectives:

By the end of this chapter, the student should be aware of the types of cardiovascular
disease, enzyme cardiac markers, protein cardiac markers and lipid and lipoprotein
cardiac markers