Page 66 - Clinical Biochemistry
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• Direct treatment costs of adverse drug reaction in internal medicine total €434 million
annually.
Pharmacogenomics (broader term)
The science of how genes affect the way people respond to drugs.
…the way our body processes drugs (pharmacokinetics).
…the interaction of drugs with receptors (pharmacodynamics).
…the treatment efficacy and adverse side effects.
Pharmacogenetics
• A subset of ‘pharmacogenomics’
• Pharmacogenomics differs from pharmacogenetics in the level of its application. Whilst
the former is for a population, the latter is more individualistic.
Figure 31: pharmacogenomics
The transition to the modern era…
Human Genome Project and technological developments expanded the possibilities.
