Page 227 - COMMUNITY PHARMACY PRACTICE
P. 227
02/04/2024
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• Doctors should review the need for continued NSAID
administration at each consultation
• In people with pre-existing heart disease or who have suffered a
heart attack or stroke, NSAIDs should only be used with caution
and only under a doctor's supervision
• Older patients, patients with type 2 diabetes or with a history of
stomach ulcers, kidney problems or at risk for heart disease are
more likely to suffer from NSAID-related complications such as
GI side effects, cardiovascular events, and kidney toxicity.
NSAIDs should be avoided, but if deemed necessary, their
usage should be monitored by a doctor.
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US BOXED WARNINGS:
• RISK OF SERIOUS CARDIOVASCULAR AND
GASTROINTESTINAL EVENTS!!
•
NSAIDs cause an increased risk of serious (CV) thrombotic
events, myocardial infarction and stroke, which can be fatal
(early in treatment and may increase with duration of use).
•
-NSAIDs cause an increased risk of serious (GI) adverse
events including bleeding, ulceration, and perforation of the
stomach or intestines, which can be fatal (at any time
during use and without warning symptoms.) Elderly
patients and patients with a prior history of peptic ulcer
disease and/or GI bleeding are at a greater risk for serious
GI events.
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