Page 224 - COMMUNITY PHARMACY PRACTICE

02/04/2024

q Skeletal muscle relaxants 452

• These medicines act at several sites in the body to reduce
muscle tone and relax tight, tense muscles, used for relief of
muscle spasm or spasticity.

• Muscle relaxants can either act directly on a muscle
peripheral or centrally .

• most drugs are centrally acting ;however , it’s not totally
clear how they do their job is uncertain way they depress
the central nervous system creating a sedative effect .

452

q Skeletal muscle relaxants 453

• Dantrolene sodium ( Dantrelax ) ..OTC is the only drugs that
is peripheral ,acting directly on muscles, It has fewer side
effects than the drugs that are centrally acting and its peak
effect isn’t felt for about five hours after it’s entrance the
bloodstream

• Tizanidine ( sirdalud ) , baclofen , methocarbamol and
chlorzoxazone ( Myolgin ) are among centrally acting skeletal
muscle relaxants.

Most common side effect include:
• blurred or double vision (change in vision ), and drowsiness

• Urine discoloration may also occur with chlorzoxazone may
orange or reddish purple.

• Methocarbamol may cause urine to turn black ,brown or
green.

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