Page 221 - COMMUNITY PHARMACY PRACTICE

02/04/2024

Aspirin and pregnancy 446

• Aspirin has potential risks, as it inhibits platelet function and
can contribute to maternal and fetal bleeding. Overall,
large trials demonstrate low-dose aspirin’s relative safety
and generally positive effects on reproductive outcomes.

• Low-dose aspirin in combination with low-dose heparin is
recommended for treatment of recurrent spontaneous
abortion in women with antiphospholipid antibodies
(disorder of coagulation that causes blood clots
(thrombosis) in both arteries and veins as well as
pregnancy-related complications such as miscarriage,
stillbirth, preterm delivery, or severe preeclampsia))

• Higher doses of aspirin (>150 mg/d) during pregnancy be
avoided (category D)

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MORE ABOUT PREGNANCY:

Paracetamol (Acetaminophen)(categoryB)

¨ Is regarded as being safe and well-tolerated during
pregnancy but doses should be taken as prescribed, due
to risk of hepatotoxicity with overdoses.

¨ But there are studies which say that paracetamol is not
totally safe as when it is used during the second trimester
it cause infertility to the child (boy).

¨ Experts say that using paracetamol and other painkillers
during pregnancy could be dangerous for baby boys as
there is a risk of undescended testicles

IBUPROFEN

¨ MAY BE USED IN THE FIRST TRIMESTER.

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