Page 216 - COMMUNITY PHARMACY PRACTICE

02/04/2024

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MANAGEMENT OF SIDE EFFECTS
W(eAcSaAn) reduce these side effects by:

1- Use asprin enteric-coated and rectal formulations which are claimed to

reduce the incidence of gastrointestinal adverse effects .
(N.B. but enteric coated preparations have a slow onset of action and are

therefore unsuitable for single dose analgesic use ).
2- Use other modified Aspirin formulations like: (buffered, effervescent…)

Bufferin , Alkasparine , Asponasr
3-Taking the dose after food to reduce the gastric ( but not necessarily
intestinal ) adverse effects
4- Concomitant use of a proton pump inhibitor to suppress the acid production
e.g : omeprazole , Ranitidine, or the prostaglandin analogue misoprostol.
(Only ………, has received an official FDA indication for protection of ulcer
in patients on non-steroidal anti-inflammatory agents or the prostaglandin
analogue misoprostol

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GIT ADVERSE DRUG REACTIONS
VARIABILITY BETWEEN NSAIDS:

¨ Indomethacin, Ketoprofen, Piroxicam :
Appear to have the highest prevalence of gastric
adverse drug reactions.
¨ Ibuprofen (low dose), Diclofenac :

Appear to have lower rates .

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