Page 214 - COMMUNITY PHARMACY PRACTICE

02/04/2024

432

Imp Drug interactions

• Aspirin potentiates the anticoagulant effect of oral
…………….s and heparin due to its antiplatelet effect so
increase risk of bleeding (Doses must be adjusted).

• Aspirin and other NSAIDs decrease renal elimination of
methotrexate and displace it from plasma protein binding
site.

• Salicylate increases hypoglycemic effect of
sulphonylureas.

• Corticosteroids decrease salicylates clearance in case of
long term, high dose salicylate therapy.

• Several NSAIDs antagonize antihypertensive effect of
several drugs including: diuretics, ACE inhibitors and B-
blockers.

• Several NSAIDs increase serum level of digoxin.
• Concurrent use of NSAIDs and quinolones may increase
432 the risk of quinolones adverse central nervous system

effects, including seizures.

433

Imp interactions/act?

• Antihypertensive effect inhibited; possible hyperkalemia
with ………..

• Monitor blood pressure,
• Monitor cardiac function, and potassium levels.

• Increased risk of hypoglycemia with………….

• Avoid concurrent use, if possible;
• Monitor blood glucose levels when changing salicylate dose.

433

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