Page 209 - COMMUNITY PHARMACY PRACTICE

02/04/2024

422

FIRST GENERATION NSAIDS:

Sulphonamides

• Nimesulide (Nilsid®, sulide®,
Nimalox®)systemic preparations are banned by
several countries for the potential risk of
hepatotoxicity ).

• an atypical NSAID, which is different from both
non-selective and selective COX-2 inhibitors.

422

SECOND GENERATION NSAIDS: 423

Advantages
Selective COX-2 inhibitors

•They are called coxibs
•Selectively blocks COX-2 responsible for inflammatory
prostaglandin formation.
•With no effect on COX-1 responsible for stomach-protecting
prostaglandins formation
•Have equal efficacy with …………side effects .
•Another particular advantage of COX-2 inhibitors is that
they do not impair the normal function of an important
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bleeding

423

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