Page 284 - Applied Pharmacognosy

Podophyllotoxin

• Podophyllotoxin (abbreviated as PPT), known as podofilox,
is a toxin lignan extracted from the roots and rhizomes of
Podophyllum species.

• P. peltatum and P. hexandrum (Berberidaceae).
• Etoposide and teniposide are semi-synthetic prototype of

Podophyllotoxin

• Etoposide and teniposide both have a polar
modified sugar unit introduced into the molecule
of podophyllotoxin. (glycosides of podophyllotoxin)

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