Page 24 - Dosage 1-part2 -ebook

30/10/2025, 00:02 Pharmaceutical Solutions & Sterile Dosage Forms

Synthetic flavors:

Examples: alcohols, aldehyde, esters, etc.

Chloroform water (0.5 ml/100 ml) with warm and sweet taste.

These flavors are preferred to natural flavors because of:

More constant composition
More readily available
Lower cost
Greater stability
More predicted incompatibility

Sweetening agents: refer to sugar containing and sugar free syrups.

Sucrose, sorbitol, mannitol, xylitol and saccharin sodium are used to improve the palatability of
oral solutions.

Sweetened, but sugar-free, preparations containing aspartame are suitable for diabetic patients
and are not cariogenic.

In many pharmaceutical products, both sweetening and flavoring agents are used together:
A cough syrup might contain sucrose (sweetening agent) to mask bitterness and cherry
flavor (flavoring agent) to create a palatable taste.

Sweetening agents: I. Sugar based sweeteners:

A. Sucrose is Used as simple syrup BP (66.7% w/w sucrose) as the base flavor in linctuses and elixirs.

Properties of Sucrose:

Colorless

Very soluble in water

Stable over a pH range (4-8)
Viscosity imparting agent

Mask both salty and bitter tastes

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