Page 104 - Pharmaceutics IV (02-06-01305)

Ophthalmic DD: routes & pharmacokinetics

• Anterior drug delivery is mainly achieved (90% of medicines)
by topical application/instillation of ophthalmic preparation.

• Topical application involves a series of events, including drug
instillation, dilution in tear fluid and diffusion through the tear
layer.

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Ophthalmic DD: routes & pharmacokinetics

• Advantages:
➢ It’s easy to administer and noninvasive
➢ The application of the therapeutic agents directly to the site

of action ensures that the therapeutic agent is available at
higher concentrations than may be achieved following oral
administration.

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Salma E. EL-Habashy